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apalutamide will lower the extent or influence of ethinylestradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with drugs which are CYP3A4 substrates may end up in reduced publicity to these remedies.The administration of oral contraceptives